Daidzein induces neuritogenesis in DRG neuronal cultures

Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.

Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development. Immunohistochemistry and ...

Painful facet joint injury induces neuronal stress activation in the DRG: implications for cellular mechanisms of pain.

The cervical facet joint is implicated as one of the most common sources of chronic neck pain, owing to its rich nociceptive innervation and susceptibility to injurious mechanical loading. Injuries to the facet joint and its ligament can induce inflammation in the joint and spinal cord. Inflammatory molecules which are known to have a role in pain can also stimulate the integrated stress respon...

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.

Visible light affects mitochondrial function and induces neuronal death in retinal cell cultures

The aim of this study was to provide "proof of principle" for the hypothesis that light would have a detrimental influence on ganglion cells in certain situations, like in glaucoma, by directly impinging on the many mitochondria in their axons within the globe. In this study primary rat retinal cultures and freshly isolated liver mitochondria were exposed to light (400-760 nm; 500-4000 lux) as ...

Network bursts in cortical neuronal cultures

Dissociated neuronal cultures provide a useful platform to study behavior and development of biological neural networks. Isolated from external inputs neural cultures generate electrical activity of their own, showing several features. The most striking feature is the phenomenon of, more or less regular, network bursts, i.e. simultaneous firing of many neurons in a relatively short time window....